PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR Meaning and
Definition
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Platelet-derived growth factor alpha receptor (PDGFRA) is a transmembrane receptor protein that plays a critical role in cell signaling and regulation of cell proliferation and differentiation. It belongs to the receptor tyrosine kinase (RTK) family and is expressed on the cell surface of various cell types, including smooth muscle cells, fibroblasts, and certain types of stem cells.
PDGFRA is activated by binding to its specific ligand, platelet-derived growth factor (PDGF), which is released by platelets and other cells in response to tissue injury or inflammation. Upon ligand binding, PDGFRA undergoes dimerization and autophosphorylation, leading to the activation of its intracellular kinase domain. This initiates a signaling cascade that triggers various cellular responses, including cell growth, migration, and survival.
Abnormal activation or mutation of PDGFRA has been implicated in the development and progression of various diseases, including cancers and fibrotic disorders. In cancer, overexpression or activating mutations of PDGFRA can lead to uncontrolled cell proliferation and tumor growth. Therefore, PDGFRA has emerged as a potential therapeutic target for the treatment of certain types of cancer.
In summary, the platelet-derived growth factor alpha receptor is a cell surface receptor protein that plays a crucial role in cell signaling and regulation of cell growth and differentiation. Its signaling pathway is involved in various physiological and pathological processes, making it an important target for therapeutic intervention.
Common Misspellings for PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR
- olatelet derived growth factor alpha receptor
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