VAULT RIBONUCLEOPROTEIN PARTICLE Meaning and
Definition
-
Vault ribonucleoprotein particle (vault) is a large, intricate cytoplasmic ribonucleoprotein complex that is found in eukaryotic cells. It is composed of multiple copies of three main components: vault RNA (vRNA), major vault protein (MVP), and several minor vault proteins (vPARP, TEP1, and VPARP-like proteins). The structure of vault resembles a hollow barrel-shaped ribonucleoprotein particle with a size of approximately 40 nm in diameter and 67 nm in length.
The vRNA, which is the core component of vault, forms a central scaffold within the particle. It is a non-coding RNA molecule that is highly conserved across different species. The MVP, the most abundant protein in vault, surrounds the vRNA and gives the particle its characteristic barrel shape. The minor vault proteins are thought to be involved in auxiliary functions such as maintaining particle stability and aiding in the transportation of vaults within the cell.
Vaults have been implicated in various cellular processes, although their exact function is still not fully understood. They are suggested to play a role in multidrug resistance by sequestering anti-cancer drugs within the particle. They have also been implicated in ribosome-free regions of the cytoplasm, suggesting a possible involvement in protein synthesis regulation. Additionally, vaults have been observed to interact with other cellular components such as telomerase, suggesting a potential role in telomere maintenance and chromosome stability.
Further research is still required to fully elucidate the complete function and significance of vault ribonucleoprotein particles within the cell.
Common Misspellings for VAULT RIBONUCLEOPROTEIN PARTICLE
- cault ribonucleoprotein particle
- bault ribonucleoprotein particle
- gault ribonucleoprotein particle
- fault ribonucleoprotein particle
- vzult ribonucleoprotein particle
- vsult ribonucleoprotein particle
- vwult ribonucleoprotein particle
- vqult ribonucleoprotein particle
- vaylt ribonucleoprotein particle
- vahlt ribonucleoprotein particle
- vajlt ribonucleoprotein particle
- vailt ribonucleoprotein particle
- va8lt ribonucleoprotein particle
- va7lt ribonucleoprotein particle
- vaukt ribonucleoprotein particle
- vaupt ribonucleoprotein particle
- vauot ribonucleoprotein particle
- vaulr ribonucleoprotein particle
- vaulf ribonucleoprotein particle
- vaulg ribonucleoprotein particle
Infographic
Add the infographic to your website:
