TRKB RECEPTOR Meaning and
Definition
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The trkB receptor, also known as the tropomyosin receptor kinase B, is a member of the tyrosine kinase receptor family that plays a crucial role in neural development and synaptic plasticity in the central nervous system (CNS). It is coded by the NTRK2 gene and is primarily expressed in regions of the brain involved in learning, memory, and emotion regulation.
The trkB receptor is activated by its ligands, the brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). Upon ligand binding, trkB receptors undergo a conformational change that leads to receptor dimerization and autophosphorylation of specific tyrosine residues in the intracellular domain. This autophosphorylation initiates a cascade of intracellular signaling events, including activation of the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways.
Activation of trkB receptors promotes neuronal survival, differentiation, and synaptic plasticity by regulating gene expression, modulating ion channel activity, and promoting the release of neurotransmitters. It is involved in a wide range of physiological processes, including axonal growth and guidance, dendritic arborization, and synaptic pruning during development and adulthood.
Abnormalities in trkB signaling have been implicated in various neurological disorders, including mood disorders, schizophrenia, epilepsy, and neurodegenerative diseases. Therefore, the trkB receptor represents a potential therapeutic target for the treatment of these conditions, and ongoing research aims to elucidate the mechanisms underlying trkB signaling and its role in brain function.
Common Misspellings for TRKB RECEPTOR
- trka receptoer
- rrkb receptor
- frkb receptor
- grkb receptor
- yrkb receptor
- 6rkb receptor
- 5rkb receptor
- tekb receptor
- tdkb receptor
- tfkb receptor
- ttkb receptor
- t5kb receptor
- t4kb receptor
- trjb receptor
- trmb receptor
- trlb receptor
- trob receptor
- trib receptor
- trkv receptor
- trkn receptor
Etymology of TRKB RECEPTOR
The word "trkB Receptor" is a scientific term used in the field of neuroscience and biochemistry. Its etymology can be broken down as follows:
1. trkB: The "trkB" term is an abbreviation of "tropomyosin receptor kinase B". This derives from the Greek word "tropē", meaning "turn", referring to tropomyosin's ability to turn muscles on and off, and "myosin", which is a class of proteins involved in muscle contraction. The "trkB" receptor is a protein in the family of tropomyosin receptor kinases.
2. Receptor: The term "receptor" comes from the Latin word "receptus", meaning "received".
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