PROTO ONCOGENE PROTEINS C ERBA Meaning and
Definition
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Proto-oncogene proteins c-erbA are a group of proteins that contribute to the normal regulation of cell growth and differentiation. They belong to the nuclear receptor superfamily and are involved in the control of gene expression. The term "proto-oncogene" indicates their potential to become oncogenes, which are genes that have the ability to transform normal cells into cancer cells when mutated or abnormally activated.
The "c-erbA" designation refers to the cellular homologs of the viral oncogene v-erbA, initially identified in avian erythroblastosis virus. The c-erbA genes are predominantly expressed in multiple tissues, including the liver, heart, and brain. They encode nuclear receptor transcription factors that bind to thyroid hormone response elements in target gene promoters, thereby regulating their expression.
Proto-oncogene proteins c-erbA play a crucial role in the development and maintenance of various organs and tissues, as well as in the control of energy metabolism. They function by forming complexes with co-repressors or co-activators, which modulate their transcriptional activity. These proteins are part of a complex network of signaling pathways and are tightly regulated to ensure proper cell proliferation and differentiation.
Alterations in proto-oncogene proteins c-erbA can lead to abnormal cell growth and differentiation, potentially resulting in the development of cancer. Therefore, understanding the function and regulation of these proteins is essential for unraveling the molecular basis of cancer development and identifying potential therapeutic targets.
Common Misspellings for PROTO ONCOGENE PROTEINS C ERBA
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