LIPID PEROXIDATION Meaning and
Definition
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Lipid peroxidation is a biochemical process that occurs when free radicals or reactive oxygen species (ROS) attack and damage the fatty acid molecules in cell membranes or lipoproteins. It involves the oxidation of polyunsaturated fatty acids (PUFAs) found in these lipid structures.
Free radicals, which are highly reactive molecules with unpaired electrons, can be generated as byproducts of normal cellular metabolism or through exposure to environmental factors such as pollution, radiation, or toxins. When excess free radicals are present in the body, they can initiate lipid peroxidation by stealing electrons from the PUFAs in cell membranes or lipoproteins. This process leads to a chain reaction wherein lipid radicals are formed and can further propagate the oxidative damage.
Lipid peroxidation can have detrimental effects on cell integrity and function. It can disrupt the fluidity and permeability of cell membranes, causing impairment in cellular processes such as signal transduction and transportation of nutrients and ions. The accumulation of lipid peroxidation products, such as lipid hydroperoxides and malondialdehyde, can also lead to inflammation, DNA damage, and cell death.
Lipid peroxidation is often used as a biomarker to assess oxidative stress levels in various diseases and conditions, including cardiovascular diseases, neurodegenerative disorders, and cancer. Antioxidants, both endogenous and exogenous, play a critical role in preventing and repairing lipid peroxidation by neutralizing or scavenging free radicals.
Common Misspellings for LIPID PEROXIDATION
- kipid peroxidation
- pipid peroxidation
- oipid peroxidation
- lupid peroxidation
- ljpid peroxidation
- lkpid peroxidation
- lopid peroxidation
- l9pid peroxidation
- l8pid peroxidation
- lioid peroxidation
- lilid peroxidation
- li-id peroxidation
- li0id peroxidation
- lipud peroxidation
- lipjd peroxidation
- lipkd peroxidation
- lipod peroxidation
- lip9d peroxidation
- lip8d peroxidation
- lipis peroxidation
Etymology of LIPID PEROXIDATION
The word "lipid peroxidation" consists of two components: "lipid" and "peroxidation".
1. Lipid:
The term "lipid" finds its origin in the Greek word "lipos", meaning "fat". It was first used in the late 19th century to describe a group of organic compounds that are insoluble in water but soluble in nonpolar solvents. "Lipid" encompasses a variety of substances, including fatty acids, oils, waxes, sterols, and triglycerides.
2. Peroxidation:
The term "peroxidation" is derived from the word "peroxide". "Peroxide" is a compound consisting of an oxygen-oxygen single bond (O-O). The word "peroxide" has its origins in the Latin word "peroxidare", which means "to pass through completely" or "to go beyond".
