KLOTHO Meaning and
Definition
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Klotho is a protein that acts as an aging suppressor and plays a significant role in the regulation of lifespan and several physiological processes. The name "klotho" is derived from the Greek goddess of fate, who is responsible for spinning the thread of life. In biological terms, klotho is a transmembrane protein that is primarily expressed in the kidneys and brain.
The klotho protein is known to exert anti-aging effects by regulating various cellular processes. It functions as a co-receptor for fibroblast growth factor (FGF) hormones and enhances their receptor binding and activation, leading to the downregulation of insulin signaling and promotion of cell survival. Klotho has also been found to regulate phosphate and calcium homeostasis, which are essential for maintaining proper bone health.
Moreover, klotho is involved in the suppression of oxidative stress and inflammation, both of which contribute to the aging process. Studies have shown that deficiencies in klotho expression lead to accelerated aging, cognitive decline, and various age-related disorders, such as cardiovascular disease and kidney dysfunction.
In recent years, klotho has emerged as a potential therapeutic target for numerous age-related conditions. Researchers are actively investigating ways to enhance klotho expression or mimic its functions to promote healthy aging and prevent age-related diseases.
Overall, klotho is a crucial protein involved in regulating lifespan and various physiological processes, and its modulation holds great promise for improving human health and extending the healthy lifespan.
Common Misspellings for KLOTHO
- jlotho
- mlotho
- llotho
- olotho
- ilotho
- kkotho
- kpotho
- kootho
- klitho
- klktho
- klltho
- klptho
- kl0tho
- kl9tho
- klorho
- klofho
- klogho
- kloyho
- klo6ho
- klo5ho
Etymology of KLOTHO
The word "klotho" has its origins in Greek mythology. In Greek, "Klothein" means "to spin". In mythology, the three Moirai (or Fates) were goddesses who controlled destiny and determined the lifespan of every person. One of the Moirai was named Klotho, which is derived from "Klothein". Klotho was responsible for spinning the thread of life, symbolizing the beginning or birth of a person. Thus, the word "klotho" is related to the act of spinning and represents the concept of fate and the creation of life.
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