HUP GENE Meaning and
Definition
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The HuP gene, also known as Hu-antigen D, is a human gene that plays a crucial role in the regulation and expression of the hematopoietic (blood-forming) stem cells. It is located on chromosome 1q21. The term "Hu" stands for "human," and the "P" refers to the P blood group system, of which HuP is a member.
The HuP gene encodes a protein that is primarily expressed in hematopoietic cells, particularly erythrocytes (red blood cells) and platelets. This protein is involved in determining the P blood group antigen on the surface of these cells. The P antigen is an important blood group antigen associated with transfusion reactions and compatibility between individuals for blood transfusions.
Mutations or variations in the HuP gene can affect the expression or structure of the P antigen, leading to different blood group phenotypes. Individuals with certain HuP gene alleles may, for example, express the P antigen at higher levels than others.
Understanding the HuP gene and its variations is important in blood transfusion and compatibility testing, as it helps predict potential blood group incompatibilities that can lead to adverse reactions. Moreover, studying the HuP gene provides insights into the genetic basis of human blood groups and contributes to our understanding of hematopoiesis, the process by which blood cells are formed.
Common Misspellings for HUP GENE
- gup gene
- bup gene
- nup gene
- jup gene
- uup gene
- yup gene
- hyp gene
- hhp gene
- hjp gene
- hip gene
- h8p gene
- h7p gene
- huo gene
- hul gene
- hu0 gene
- hup fene
- hup vene
- hup bene
- hup hene
- hup yene
