Hepatocyte Growth Factor (HGF) is a naturally occurring protein that plays a crucial role in cell growth, tissue repair, and regeneration. It is primarily produced and secreted by cells in the liver, although it can also be found in various other tissues and organs.
The main function of HGF is to stimulate the growth and division of hepatocytes, which are the primary cells of the liver. It acts as a potent mitogen, promoting cell proliferation and tissue regeneration in response to injury or damage. Additionally, HGF also has angiogenic properties, meaning it can stimulate the formation of new blood vessels in the liver.
HGF exerts its effects by binding to a specific receptor called c-Met, which is present on the surface of target cells. Once bound, this interaction activates a cascade of intracellular signaling pathways, leading to cell proliferation, migration, and survival.
Beyond its role in liver regeneration, HGF has also been implicated in various other physiological processes, including embryogenesis, wound healing, tissue development, and homeostasis. Dysregulation or abnormal levels of HGF have been associated with several diseases, including liver diseases, cancer, and fibrosis.
In summary, Hepatocyte Growth Factor (HGF) is a protein that stimulates the growth and repair of hepatocytes, the primary cells of the liver. It plays a critical role in tissue regeneration, wound healing, and angiogenesis, among other biological processes.
