GANGLIONEUROMAS Meaning and
Definition
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Ganglioneuromas are benign tumors that arise from neural crest cells and typically develop in the autonomic ganglia along the peripheral nervous system. These tumors are composed of ganglion cells, nerve fibers, and supporting stromal cells, and may occur in various locations within the body, including the adrenal glands, retroperitoneum, mediastinum, and gastrointestinal tract.
Ganglioneuromas are characterized by their slow growth rate, lack of invasion into surrounding tissues, and absence of metastatic potential. These tumors commonly present as asymptomatic or incidentally discovered masses, with symptoms only arising when they compress adjacent structures or reach significant size. Symptoms may include pain, bowel obstruction, urinary troubles, or hormonal imbalances, depending on the location of the tumor.
Histologically, ganglioneuromas exhibit a well-differentiated appearance, with the presence of mature ganglion cells and nerve fibers arranged in a spindle-shaped stroma. They are often encapsulated and exhibit low cellularity. Ganglioneuromas are typically diagnosed through imaging techniques, such as computed tomography (CT) or magnetic resonance imaging (MRI), which help in visualizing the size, location, and characteristics of the tumor.
Surgical resection is the mainstay treatment for ganglioneuromas, with the goal of complete removal of the tumor while preserving nearby vital structures and nerves. Prognosis of ganglioneuromas is generally excellent, as these tumors rarely recur or metastasize. However, long-term follow-up is often necessary to ensure the absence of recurrence or development of other neuroendocrine tumors in individuals with hereditary conditions associated with ganglioneuromas, such as multiple endocrine neoplasia type 2B or
Common Misspellings for GANGLIONEUROMAS
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Etymology of GANGLIONEUROMAS
The word "ganglioneuromas" is derived from two main components: "ganglio-" and "-neuromas".
1. Ganglio-: This prefix comes from the Greek word "gánglion" (γάγγλιον), meaning "knot" or "ganglion". In the context of medicine, a ganglion refers to a collection or group of nerve cells. It is often used to describe a mass or a benign tumor involving nerve tissue.
2. -Neuromas: This suffix comes from the Greek word "neuron" (νεῦρον), meaning "nerve". In medical terminology, "-neuromas" is used to denote a tumor or pathological growth that involves nerve tissue.
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