ERBA GENE Meaning and
Definition
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The erbA gene is a term used in genetics and molecular biology to refer to a specific group of genes that encode for nuclear receptors known as thyroid hormone receptors (TRs). These receptors play a vital role in regulating the expression of various genes involved in growth, development, and metabolism.
The erbA gene family consists of three members: erbAα, erbAβ, and erbAγ. These genes are located on different chromosomes and are expressed in various tissues and developmental stages. They encode for proteins that function as transcription factors, binding to specific DNA sequences called thyroid hormone response elements (TREs) located in the promoter regions of target genes.
The erbA genes are named after the oncogene v-erbA, which was initially discovered in avian erythroblastosis virus, a retrovirus that causes tumor formation in chickens. The erbA genes are considered tumor suppressor genes because they have the ability to inhibit cell proliferation and promote cell differentiation.
Mutations or dysregulation of erbA genes have been implicated in various diseases, including thyroid hormone resistance syndrome, congenital hypothyroidism, and certain types of cancers. Studying the erbA gene and its functions provides insights into the molecular mechanisms underlying these diseases and may contribute to the development of potential therapeutic options.
In summary, the erbA gene refers to a group of genes that encode for thyroid hormone receptors, playing a critical role in gene regulation, growth, development, and metabolism. Dysregulation or mutations in these genes can have significant implications for human health and disease.
Common Misspellings for ERBA GENE
- wrba gene
- srba gene
- drba gene
- rrba gene
- 4rba gene
- 3rba gene
- eeba gene
- edba gene
- efba gene
- etba gene
- e5ba gene
- e4ba gene
- erva gene
- erna gene
- erha gene
- erga gene
- erbz gene
- erbs gene
- erbw gene
- erbq gene
Etymology of ERBA GENE
The term "erbA gene" is derived from the combined abbreviation of the original name "Erythroblastosis virus E26 oncogene homolog 1" (ERBA1). The ERBA1 gene was first identified as an oncogene in the genome of the avian erythroblastosis virus, which causes a type of cancer called erythroblastosis in birds. The gene was later discovered to have a counterpart in humans, and the name "erbA" was used as a short form to refer to this human gene. The word "gene" itself originates from the Greek word "genos", meaning "origin" or "birth", and it refers to a functional unit of heredity that carries information for the production of a specific protein or the control of a certain characteristic.
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