How Do You Spell DIHYDROFOLATE DEHYDROGENASE?

1. Dihydrofolate dehydrogenase is an enzyme that plays a crucial role in the metabolism of folic acid and folate derivatives in living organisms. It is specifically responsible for the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF) through the process of oxidation. This enzymatic reaction is essential for various biochemical reactions, particularly those involved in the synthesis of DNA, RNA, and certain amino acids.

   Dihydrofolate dehydrogenase is a key enzyme in the folate cycle, a metabolic pathway that regulates the availability of THF, which serves as a coenzyme and carrier of one-carbon units involved in numerous biological processes. By catalyzing the conversion of DHF to THF, this enzyme participates in the replenishment of THF levels, ensuring the continuous availability of this vital coenzyme for cellular reactions.

   The activity of dihydrofolate dehydrogenase is tightly regulated, as imbalances in folate metabolism can have detrimental effects on cellular function and overall health. In fact, inhibitors of this enzyme, such as certain medications, have been used in the treatment of cancer and microbial infections by selectively inhibiting the growth of cancer cells or pathogens that rely heavily on folate metabolism.

   In summary, dihydrofolate dehydrogenase is an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential coenzyme involved in various biological processes including DNA and RNA synthesis. Its function is critical for maintaining proper folate metabolism and ensuring normal cellular function.

Common Misspellings for DIHYDROFOLATE DEHYDROGENASE

The word "dihydrofolate dehydrogenase" has its etymology derived from the combination of several terms:

1. Dihydrofolate: "Dihydro" comes from the Greek word "díhydro", meaning "two hydrogen atoms", and "folate" refers to the compound folic acid, which is involved in various processes within the body.

2. Dehydrogenase: "De" comes from the Latin prefix "de-", which means to remove or take away, and "hydrogen" refers to the element hydrogen. "Dehydrogenase" is a class of enzymes that catalyze the removal of hydrogen atoms from molecules.

Therefore, "dihydrofolate dehydrogenase" can be understood as an enzyme that removes hydrogen atoms from dihydrofolate, a compound involved in folic acid metabolism.