DEAMIDISATION Meaning and
Definition
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Deamidation is a chemical process that involves the removal of the amide group (-CONH2) from a molecule, resulting in the formation of a carboxyl group (-COOH) and the release of ammonia (NH3). This process is often catalyzed by enzymes called deamidases.
Deamidation commonly occurs in proteins and peptides, where the amide group is cleaved from asparagine or glutamine residues. Asparagine deamidation is the more prevalent type and is facilitated by the hydrolysis of the peptide bond between the asparagine and the preceding amino acid. Glutamine deamidation, on the other hand, involves the conversion of glutamine to glutamic acid.
The deamidation of proteins and peptides can have significant effects on their structure and function. It can lead to changes in the charge distribution, conformational alterations, and alterations in protein-protein interactions. These modifications may impact protein stability, enzymatic activity, immune recognition, and other biochemical processes.
Deamidisation is a related term that describes the act or process of inducing deamidation in a substance. For example, deamidisation of proteins can be achieved through various methods, such as exposure to heat, changes in pH, or enzymatic treatment. Scientists and researchers often study deamidation and deamidisation to understand the impact of these modifications on the structure and function of molecules, contributing to advancements in fields like biochemistry, proteomics, and pharmaceutical development.
Common Misspellings for DEAMIDISATION
- seamidisation
- xeamidisation
- ceamidisation
- feamidisation
- reamidisation
- eeamidisation
- dwamidisation
- dsamidisation
- ddamidisation
- dramidisation
- d4amidisation
- d3amidisation
- dezmidisation
- desmidisation
- dewmidisation
- deqmidisation
- deanidisation
- deakidisation
- deajidisation
- deamudisation
Etymology of DEAMIDISATION
The word "deamidisation" is formed from the prefix "de-" meaning "undoing" or "removal" and the word "amidation".
The term "amidation" refers to a chemical process of introducing or reacting with an amide group (-CONH2) within a molecule. When the prefix "de-" is added to it, it indicates the opposite action, implying the removal or reversal of the amidation process.
Therefore, "deamidisation" can be understood as the act or process of undoing or removing the amidation within a compound or molecule.
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