How Do You Spell COMPLEMENT HEMOLYTIC ACTIVITY ASSAY?

1. The Complement Hemolytic Activity Assay is a laboratory test that measures the ability of the complement system in the bloodstream to lyse (break open) red blood cells (hemolysis). The complement system is a part of the body's immune system and consists of a group of proteins that work together to defend against pathogens and promote inflammation.

   In this assay, the patient's serum (a component of blood) is combined with a standardized suspension of red blood cells. The activation of the complement system by the presence of the patient's antibodies on the red blood cells leads to the formation of a membrane attack complex (MAC), which ultimately results in the lysis of the red blood cells.

   The degree of hemolysis caused by the complement system is measured using various methods, such as spectrophotometry or visual inspection. By quantifying the level of complement-mediated hemolysis, the complement hemolytic activity assay can provide valuable information about the functional activity of the complement system.

   This assay is primarily used in the diagnosis and monitoring of various autoimmune disorders, such as systemic lupus erythematosus and hereditary angioedema, as well as in the assessment of complement deficiencies and the evaluation of complement-targeted therapies. The results of the assay can help healthcare practitioners in determining the appropriate treatment strategy and monitoring the effectiveness of interventions.

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