COMPLEMENT FACTOR H Meaning and
Definition
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Complement Factor H (CFH) is a vital protein found in the human body that plays a crucial role in regulating the activity of the complement system, a part of the immune system responsible for identifying and eliminating pathogens, toxins, and damaged cells. CFH specifically functions as a negative regulator of the complement cascade.
The complement system is composed of a group of more than 30 proteins that work together to destroy foreign invaders and maintain tissue homeostasis. However, an overactive complement system can lead to tissue damage by attacking healthy cells. Here comes the role of CFH - it prevents excessive complement activation by binding to self-markers on healthy cells, inhibiting the complement proteins from initiating an attack.
The gene encoding CFH is known to be located on human chromosome 1q32 and is associated with various diseases including age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), and dense deposit disease (DDD). Mutations or dysregulation of CFH can disrupt its normal function, leading to abnormal complement activation, inflammation, and tissue damage.
Understanding the structure and function of CFH is crucial in unraveling the pathogenesis of complement-related diseases and developing potential therapeutic strategies. Ongoing research is focused on investigating CFH interactions with other complement proteins, studying the impact of CFH mutations on complement regulation, and developing drugs targeting the CFH pathway to treat complement-related diseases.
Common Misspellings for COMPLEMENT FACTOR H
- xomplement factor h
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- conplement factor h
- cokplement factor h
- cojplement factor h
- comolement factor h
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Similar spelling words for COMPLEMENT FACTOR H
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