COLLAGEN LYSYL HYDROXYLASE Meaning and
Definition
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Collagen lysyl hydroxylase is an enzyme responsible for catalyzing a crucial post-translational modification in the synthesis of collagen molecules. Collagen, the most abundant protein in the human body, is a major constituent of various connective tissues such as skin, tendons, ligaments, and bones.
Collagen lysyl hydroxylase specifically acts on the lysine residues within the collagen polypeptide chains. It adds hydroxyl groups (-OH) to these lysine residues, transforming them into hydroxylysine. This enzymatic hydroxylation reaction occurs within the lumen of the endoplasmic reticulum, which is the site of collagen synthesis.
The addition of hydroxylysine to collagen plays a critical role in stabilizing and strengthening the collagen molecules. Hydroxylysine residues, through intra- and intermolecular cross-linking, facilitate the formation of covalent bonds between collagen chains. These cross-links are essential for the integrity and mechanical properties of collagen-rich tissues.
Deficiencies or mutations in collagen lysyl hydroxylase can lead to disorders such as Ehlers-Danlos syndrome, which is characterized by weakened connective tissues. Inadequate hydroxylation of lysine residues can impair collagen's ability to form stable fibrils, resulting in reduced tensile strength and flexibility of tissues.
Understanding the role of collagen lysyl hydroxylase and its hydroxylation activity is crucial for unraveling the mechanisms behind collagen-related diseases and exploring potential therapeutic interventions.
Common Misspellings for COLLAGEN LYSYL HYDROXYLASE
- xollagen lysyl hydroxylase
- vollagen lysyl hydroxylase
- follagen lysyl hydroxylase
- dollagen lysyl hydroxylase
- cillagen lysyl hydroxylase
- ckllagen lysyl hydroxylase
- clllagen lysyl hydroxylase
- cpllagen lysyl hydroxylase
- c0llagen lysyl hydroxylase
- c9llagen lysyl hydroxylase
- coklagen lysyl hydroxylase
- coplagen lysyl hydroxylase
- coolagen lysyl hydroxylase
- colkagen lysyl hydroxylase
- colpagen lysyl hydroxylase
- coloagen lysyl hydroxylase
- collzgen lysyl hydroxylase
- collsgen lysyl hydroxylase
- collwgen lysyl hydroxylase
- collqgen lysyl hydroxylase
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