CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS Meaning and
Definition
-
Class I major histocompatibility antigens, also known as MHC class I antigens, are cell-surface proteins found in humans and other vertebrates. They play a crucial role in the immune system and are encoded by genes located in a specific region of the major histocompatibility complex, or MHC.
MHC class I antigens are primarily found on the surface of all nucleated cells in the body, including white blood cells, and serve as key molecules for the recognition and presentation of antigens to the immune system. They consist of two main components: a transmembrane protein called the MHC class I heavy chain and a smaller protein known as beta-2 microglobulin. The heavy chain contains a peptide-binding groove that can accommodate a wide range of small protein fragments, derived from both intracellular and extracellular sources.
The major function of MHC class I antigens is to present these peptide fragments to cytotoxic T cells (also called killer T cells) as a means of immune surveillance. Cytotoxic T cells recognize the complex formed by the MHC class I antigen and the peptide fragment, allowing them to distinguish between normal and infected or cancerous cells. If a cell is detected as abnormal, the cytotoxic T cells can kill the infected or cancerous cell to prevent further spread of diseases.
In addition to their role in immune recognition, MHC class I antigens also play a critical role in mediating tissue compatibility between individuals, as they are responsible for the rejection of transplanted tissues or organs. This is because differences in MHC class I antigens can be recognized by the recipient's immune system as foreign, leading to an immune response against the transplanted tissue.
Overall, MHC class I major histocompatibility antigens play a fundamental role
Common Misspellings for CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS
- xlass i major histocompatibility antigens
- vlass i major histocompatibility antigens
- flass i major histocompatibility antigens
- dlass i major histocompatibility antigens
- ckass i major histocompatibility antigens
- cpass i major histocompatibility antigens
- coass i major histocompatibility antigens
- clzss i major histocompatibility antigens
- clsss i major histocompatibility antigens
- clwss i major histocompatibility antigens
- clqss i major histocompatibility antigens
- claas i major histocompatibility antigens
- clazs i major histocompatibility antigens
- claxs i major histocompatibility antigens
- clads i major histocompatibility antigens
- claes i major histocompatibility antigens
- claws i major histocompatibility antigens
- clasa i major histocompatibility antigens
- clasz i major histocompatibility antigens
- clasx i major histocompatibility antigens
Similar spelling word for CLASS I MAJOR HISTOCOMPATIBILITY ANTIGENS
Infographic
Add the infographic to your website:
