How Do You Spell CEPHALOSPORIN ACYLASE?

1. Cephalosporin Acylase is an enzyme that plays a crucial role in the production of cephalosporin antibiotics. It belongs to the class of enzymes called hydrolases, which catalyze the hydrolysis of various chemical bonds. Specifically, cephalosporin acylase catalyzes the hydrolysis of the amide bond in the penicillin-containing nucleus of the cephalosporin antibiotics.

   The enzyme acts on cephalosporins by cleaving the side chain from the nucleus, resulting in the formation of a 7-aminocephalosporanic acid (7-ACA) derivative. This process is an essential step in the industrial production of semi-synthetic cephalosporin antibiotics, as the 7-ACA derivative serves as a precursor for the synthesis of various cephalosporin antibiotics.

   Cephalosporin acylase is widely used in the pharmaceutical industry as a biocatalyst due to its specificity and efficiency in the hydrolysis of cephalosporins. Its usage allows for the production of cephalosporin antibiotics with improved pharmacological properties, such as increased effectiveness and decreased side effects.

   This enzyme is typically produced by certain microbial organisms through fermentation processes. Due to its significance in the synthesis of cephalosporin antibiotics, cephalosporin acylase has been extensively studied, and various genetic engineering techniques have been employed to optimize its production and enhance its catalytic properties.

Common Misspellings for CEPHALOSPORIN ACYLASE

The word "Cephalosporin Acylase" is a compound term composed of two main parts:

1. "Cephalosporin": The term "cephalosporin" originated from the name of the mold Cephalosporium acremonium, from which the compound was first isolated. Cephalosporins are a class of antibiotics that are structurally similar to penicillin and are commonly used to treat various bacterial infections.

2. "Acylase": The term "acylase" comes from the word "acyl", which refers to a functional group composed of a carbon atom attached to a double-bonded oxygen and a single-bonded oxygen (carbonyl group). The suffix "-ase" is commonly used to denote enzymes, which are biological catalysts that facilitate chemical reactions.