Pronunciation: [bjˈuːfɐd͡ʒˌɪn] (IPA) 
The word "bufagin" is spelled with a "g" instead of a "j" because it comes from a Latin word that uses the letter "g." In IPA phonetic transcription, it is spelled /bjuːˈfædʒɪn/ with the "j" sound being represented by the "dʒ" symbol. Bufagin is a cardiotonic steroid that is found in various species of toad and is known to have medicinal properties. Its correct spelling is important for scientific research and medical applications.
Bufagin is a toxic steroid compound that belongs to the family of bufadienolides. It is derived from the secretion of certain species of toads, particularly those found in the Bufonidae family. Bufagin possesses potent cytotoxic properties, making it an important compound of interest in the field of medicinal chemistry.
This compound exhibits inhibitory effects on various key enzymes, such as Na+/K+-ATPase and H+/K+-ATPase, which are involved in regulating ion transport across cell membranes. Moreover, bufagin has been found to exhibit anticancer activities by inducing apoptosis and inhibiting proliferation in cancer cells. These properties make it a potential candidate for developing new therapeutic strategies against cancer.
Furthermore, the pharmacological properties of bufagin have also been explored in the context of cardiovascular diseases. Studies have shown that this compound exhibits cardiotonic effects by enhancing the contractility of the heart muscles. Additionally, bufagin is known to have antiarrhythmic properties by regulating the electrical activity of the heart. These properties have suggested its potential application as a therapeutic agent for certain cardiac conditions.
In conclusion, bufagin is a toxic steroid compound derived from toads, possessing potent cytotoxic properties and displaying inhibitory effects on key enzymes. Its anticancer properties, ability to regulate ion transport, and cardiotonic effects make it a compound of interest for potential pharmaceutical applications in the fields of oncology and cardiology.
A substance, C9H12O2, having properties similar to those of digitalis, contained in the secretion of the poison glands of a tropical toad, Bufo agua, and probably in that of the skin glands of other species of toads.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
The word "bufagin" is derived from the chemical compound "bufotenin". The term "bufotenin" was coined by German chemist Hand-Werner Kosterlitz in 1934. The name "bufotenin" is a combination of "buf" which is short for Bufo, the genus name of toads, and "tenin" which is derived from the substance serotonin. This compound was first isolated from the skin of the Colorado River toad, also known as Bufo alvarius, hence the association with the name "bufagen" and the toad species.
