ALU SEQUENCE Meaning and
Definition
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The "alu sequence" refers to a repetitive DNA sequence commonly found within the human genome. The term "alu" is derived from its recognition by the restriction enzyme AluI, which cuts the DNA at specific sites within this sequence.
The alu sequence consists of a repetitive stretch of about 300 nucleotides, predominantly adenine (A) and thymine (T). It is classified as a SINE (Short Interspersed Nuclear Element), a type of transposable element present in large numbers in the genome. SINEs are non-coding segments of DNA that can move around in the genome and have the ability to duplicate themselves.
Alu sequences are estimated to make up around 10% of the human genome, with over a million copies dispersed throughout chromosomes. They are highly conserved across individuals, suggesting their evolutionary importance. While alu sequences themselves do not have specific functions, they have been associated with gene regulation, as they can act as enhancers or silencers of nearby genes.
The presence of alu sequences has also been linked to certain genetic disorders and diseases. Mutations or alterations within these sequences can cause gene disruption, chromosomal rearrangements, or other genetic abnormalities.
Overall, the alu sequence is a repetitive DNA element that plays a significant role in the structure and function of the human genome, contributing to its complexity and diversity.
Common Misspellings for ALU SEQUENCE
- zlu sequence
- slu sequence
- wlu sequence
- qlu sequence
- aku sequence
- apu sequence
- aou sequence
- aly sequence
- alh sequence
- alj sequence
- ali sequence
- al8 sequence
- al7 sequence
- alu aequence
- alu zequence
- alu xequence
- alu dequence
- alu eequence
- alu wequence
- alu swquence
Etymology of ALU SEQUENCE
The term "alu sequence" is derived from the name of a repetitive DNA sequence called the Alu element. The Alu element is a short, approximately 300 base pair long sequence that is present in high numbers in the human genome. This sequence was first discovered in the 1970s by a group of researchers at the University of Rochester. The name "Alu" was given to this repetitive sequence because it has two recognition sites for the restriction enzyme AluI. The Alu element is thought to have originated from the small cytoplasmic 7SL RNA, which is involved in protein synthesis, and has been inserted into the human genome over evolutionary time. Today, Alu elements make up about 10% of the human genome and have been associated with various genetic phenomena and diseases.
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