AMIDOPHOSPHORIBOSYLTRANSFERASE Meaning and
Definition
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Amidophosphoribosyltransferase is an enzyme that plays a crucial role in nucleotide biosynthesis, specifically in the conversion of phosphoribosylpyrophosphate (PRPP) to 5-phosphoribosylamine (PRA). This enzyme is a key component of the purine biosynthesis pathway, which is responsible for the production of purine nucleotides, the building blocks of DNA and RNA.
The amidophosphoribosyltransferase catalyzes the transfer of an amidine group from glutamine to PRPP, resulting in the formation of PRA. This reaction occurs in the presence of magnesium ions and requires both PRPP and glutamine as substrates. The enzyme acts as a catalyst, speeding up the conversion process without being consumed.
Amidophosphoribosyltransferase is an essential enzyme for cells to maintain an adequate supply of purine nucleotides for DNA and RNA synthesis. Its activity is tightly regulated to ensure balanced nucleotide pools and prevent excessive purine synthesis.
Mutations or deficiencies in amidophosphoribosyltransferase can lead to various disorders, such as PRPP synthetase superactivity, which results in overproduction of purine nucleotides and the development of gout. Targeting this enzyme with specific inhibitors has also shown potential as a therapeutic approach in certain cancers where the purine synthesis pathway is dysregulated.
In conclusion, amidophosphoribosyltransferase is an enzyme involved in the biosynthesis of purine nucleotides, playing a crucial role in maintaining proper nucleotide pools for vital cellular processes.
Common Misspellings for AMIDOPHOSPHORIBOSYLTRANSFERASE
- zmidophosphoribosyltransferase
- smidophosphoribosyltransferase
- wmidophosphoribosyltransferase
- qmidophosphoribosyltransferase
- anidophosphoribosyltransferase
- akidophosphoribosyltransferase
- ajidophosphoribosyltransferase
- amudophosphoribosyltransferase
- amjdophosphoribosyltransferase
- amkdophosphoribosyltransferase
- amodophosphoribosyltransferase
- am9dophosphoribosyltransferase
- am8dophosphoribosyltransferase
- amisophosphoribosyltransferase
- amixophosphoribosyltransferase
- amicophosphoribosyltransferase
- amifophosphoribosyltransferase
- amirophosphoribosyltransferase
- amieophosphoribosyltransferase
- amidiphosphoribosyltransferase
Etymology of AMIDOPHOSPHORIBOSYLTRANSFERASE
The word "Amidophosphoribosyltransferase" is derived from multiple parts:1. Amido: Derived from the Latin word "amidum", meaning starch or ferment. In chemistry, "amido" is used to indicate the presence of an amide group (-CONH2).2. Phospho: Derived from the Greek word "phosphoros", meaning light-bringer. In chemistry, "phospho" is used to indicate the presence of a phosphate group (-PO4).3. Ribose: Derived from the Latin word "ribes", meaning currant. Ribose is a sugar molecule commonly found in RNA.4. Transferase: Derived from the Latin word "transferre", meaning to convey or transfer. In biochemistry, a transferase is an enzyme that facilitates the transfer of a functional group (such as an amido or phosphate group) from one molecule to another.
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